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Publications
Center use has resulted in the publication of over 150 articles in journals that include: the American Journal of Physiology, the EMBO Journal, the Journal of Biological Chemistry, Molecular Biology of the Cell, and Proceedings of the National Academy of Sciences. Publications are grouped by core usage.


Enter the name for this tabbed section: Cellular Physiology
Carattino MD, Hughey RP, Kleyman TR. Proteolytic processing of the epithelial sodium channel gamma subunit has a dominant role in channel activation. J Biol Chem. 283:25290-5, 2008. PMC2533072

Khandelwal P, Ruiz WG, Balestreire-Hawryluk E, Weisz OA, Goldenring JR, Apodaca G. Rab 11a dependent exocytosis of discoidal/fusiform vesicles in bladder umbrella cells. Proc Natl Acad Sci U S A. 105:15773-8, 2008. PMC257297

Passero CJ, Mueller GM, Rondon-Berrios H, Tofovic SP, Hughey RP, Kleyman TR. Plasmin activates epithelial Na+ channels by cleaving the gamma subunit. J Biol Chem. 283:36586-91, 2008. PMC2605981

Hallows KR, Wang H, Edinger RS, Butterworth MB, Oyster NM, Lil H, Buck J, Levin LR, Johnson JP, Pastor-Soler N. Novel regulation of epithelial Na+ transport by soluble adenlyl cyclase in kidney collecting duct cells. J Biol Chem. 284:5774-83, 2009. PMC2645828

Yu W, Khandelwal P, Apodaca G. Distinct apical and basolateral membrane requirements for stretch-induced membrane traffic at the apical surface of bladder umbrella cells. Mol Biol Cell. 20:282-95, 2009. PMC2613117

Maarouf AB, Sheng N, Chen J, Winarski KL, Okumura S, Carattino MD, Boyd CR, Kleyman TR, Sheng S. Novel Determinants of Epithelial Sodium Channel Gating within Extracellular Thumb Domains. J Biol Chem. 284:7756-65, 2009. PMC2658069

Hallows KR, Alzamora R, Li H, Gong F, Smolak C, Neumann D, Pastor-Soler NM. AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells. Am J Physiol Cell Physiol. 296:C672-81, 2009. PMC2670645

Edeling MA, Sanker S, Shima T, Umasankar PK, Höning S, Kim HY, Davidson LA, Watkins SC, Tsang M, Owen DJ, Traub LM. Structural requirements for PACSIN/Syndapin operation during zebrafish embryonic notochord development. PLoS One 4:e8150, 2009. PMC2780292.

Fölsch H, Mattila PE, and Weisz OA. Taking the scenic route: Biosynthetic traffic to the plasma membrane in polarized epithelial cells. Traffic. 10:972-981, 2009. PMC2786770

Khandelwal P, Abraham SN, Apodaca G. Cell biology and physiology of the uroepithelium. Am J Physiol Renal Physiol. 297:F1477-501, 2009. PMC2801337.

Cui S, Guerriero CJ, Szalinski CM, Kinlough CL, Hughey RP, Weisz OA. OCRL1 function in renal epithelial membrane traffic. Am J Physiol Renal Physiol. 298:F335-45, 2010. PMC2822509.

Buck TM, Kolb AR, Boyd CR, Kleyman TR, and Brodsky JL. The endoplasmic reticulum-associated degradation of the epithelial sodium channel requires a unique complement of molecular chaperones. Mol Biol Cell. 21:1047-58, 2010. PMC2836957

Gong F, Alzamora R, Smolak C, Li H, Naveed S, Neumann D, Hallows KR, Pastor-Soler NM. Vacuolar H+-ATPase apical accumulation in kidney intercalated cells is regulated by PKS and AMP-activated protein kinase. Am J Physiol Renal Physiol. 298:F1162-R1169. 2010. PMC2867405

Myerburg, MM, King, JD, Oyster, NM, Fitch, AC, Magill, A, Baty, CJ, Watkins, SC, Kolls, JK, Pilewski, JM, Hallows, KR. AMPK agonists ameliorate sodium and fluid transport and inflammation in CF airway epithelial cells. Am J Respir Cell Mol Biol. 42: 676-84, 2010. PMC2891496

Khandelwal P, Ruiz WG, Apodaca G. Compensatory endocytosis in bladder umbrella cells occurs through an integrin-regulated and RhoA- and dynamin-dependent pathway. EMBO J. 29:1961-75, 2010. PMC2892371

Li, H, Thali, RF, Smolak, C, Gong, F, Alzamora, R, Wallimann, T, Scholz, R, Pastor-Soler, NM, Neumann, D, Hallows, KR. Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells. Am J Physiol Renal Physiol. 299: F167-77, 2010. PMC2904179

Hallows, KR, Bhalla, V, Oyster, NM, Wijngaarden, MO, Lee, JK, Li, H, Chandran, S, Xia, X, Huang, Z, Chalkley, RJ, Burlingame, AL, and Pearce, D. Phosphopeptide screen uncovers novel Nedd4-2 phosphorylation sites that potentiate its inhibition of the epithelial Na+ channel. J Biol Chem. 285: 21671-8, 2010. PMC2898378

Alzamora R, Thali RF, Gong F, Smolak C, Li H, Baty CJ, Bertrand CA, Auchli Y, Brunisholz RA, Neumann D, Hallows KR, Pastor-Soler NM. PKA regulates vacuolar H+-ATPase localization and activity via direct phosphorylation of the subunit in kidney cells. J Biol Chem. 285:24676-85, 2010. PMC2915704

Banerjee SK, Wang DW, Alzamora R, Huang XN, Pastor-Soler NM, Hallows KR, McGaffin KR, Ahmad F. SGLT1, a novel cardiac glucose transporter, mediates increased glucose uptake in PRKAG2 cardiomyopathy. J Mol Cell Cardiol. 49: 683-92, 2010. PMC2932762

Pedersen GA, Chakraborty S, Steinhauser AL, Traub LM, Madsen M. AMN Directs Endocytosis of the Intrinsic Factor-Vitamin B Receptor Cubam by Engaging ARH or Dab2. Traffic. 11:706-720. 2010.: PMC2964065

Mo D, Potter BA, Bertrand CA, Hildebrand JD, Bruns JR, and Weisz, OA. Nucleofection disrupts tight junction fence function to alter membrane polarity of renal epithelial cells. Am J Physiol Renal Physiol. 299: F1178-84, 2010. PMC2980404

Alzamora R, Gong F, Rondanino C, Lee JK, Smolak C, Pastor-Soler NM, Hallows KR. AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells. Am J Physiol Renal Physiol. 299:F1308-19, 2010. PMC3006313

Mueller GM, Maarouf AB, Kinlough CL, Sheng N, Kashlan OB, Okumura S, Luthy S, Kleyman TR, Hughey RP. Cys-palmitoylation of the beta subunit modulates gating of the epithelial sodium channel. J Biol Chem. 285: 30453-30462, 2010. PMC2945538

Kashlan, OB, Boyd CR, Argyropoulos C, Okumora S, Hughey RP, Grabe M, Kleyman TR. Allosteric inhibition of the epithelial Na+ channel through peptide binding at peripheral finger and thumb domains. J Biol Chem. 285: 35216-35223, 2010. PMC2966135

Kashlan OB, Adelman JL, Okumura S, Blobner BM, Zuzek Z, Hughey RP, Kleyman TR, Grabe M. Constraint based, homology model of the extracellular domain of the epithelial Na+ channel subunit reveals a mechanism of channel activation by proteases. J Biol Chem. 286: 649-60, 2011. PMC3013024

Passero CJ, Carattino MD, Kashlan OB, Myerburg MM, Hughey RP, Kleyman TR. Defining an inhibitory domain in the gamma subunit of the epithelial sodium channel. Am J Physiol Renal Physiol. 299: F854-61, 2010. PMC2957262

Yu W, Hill WG, Apodaca G, Zeidel ML. Expression and distribution of transient receptor potential (TRP) channels in bladder epithelium. Am J Physiol Renal Physiol. 300:F49-59, 2011. PMC3023226

Abi-Antoun T, Shi S, Tolino LA, Kleyman TR, Carattino MD. Second transmembrane domain modulates epithelial sodium channel gating in response to shear stress. Am J Physiol Renal Physiol. 300: F1089-95, 2011. PMC3094055

Shi S, Ghosh DD, Okumura S, Carattino MD, Kashlan OB, Sheng S, Kleyman TR. Base of the thumb domain modulates epithelial sodium channel gating. J Biol Chem. 286: 14753-61, 2011. PMC3083234

Tolino LA, Okumura S, Kashlan OB, Carattino MD. Insights into the mechanism of pore opening of acid-sensing ion channel 1A. J Biol Chem. 286: 16297-307, 2011. PMC3091236

Winarski KL, Sheng N, Chen J, Kleyman TR, Sheng S. Extracellular allosteric regulatory subdomain within the gamma subunit of the epithelial Na+ channel. J Biol Chem 285: 26088-26096, 2010.
PMC2924010

Rondanino C, Poland PA, Kinlough CL, Li H, Rbaibi Y, Myerburg MM, Al-Bataineh MM, Kashlan OB, Pastor-Soler NM, Hallows KR, Weisz OA, Apodaca G, Hughey RP. Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells. Am J Physiol Renal Physiol. 2011, 301:F622-33. PMC3174547

Pan J, Chen Q, Willenbring D, Yoshida K, Tillman T, Kashlan OB, Cohen A, Kong XP, Xu Y, Tang P. Structure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine. Nat Commun. 2012 Mar 6;3:714. PMC3316889

Shi S, Blobner BM, Kashlan OB, Kleyman TR. Extracellular finger domain modulates the response of the epithelial sodium channel to shear stress. J Biol Chem. 287: 15439-44, 2012. PMC3346134
Kashlan OB, Kleyman TR. Epithelial Na+ channel regulation by cytoplasmic and extracellular factors. Exp Cell Res. 318: 1011-9, 2012. PubMed PMID: 22405998.

Kinlough CL, Poland PA, Gendler SJ, Mattila PE, Mo D, Weisz OA, Hughey RP. Core-glycosylated mucin-like repeats from MUC1 are an apical targeting signal. J Biol Chem. 2011, 286:39072-81. PMC3234732.

Passero CJ, Mueller GM, Myerburg MM, Carattino MD, Hughey RP, Kleyman TR. TMPRSS4-dependent activation of the epithelial sodium channel requires cleavage of the γ-subunit distal to the furin cleavage site. Am J Physiol Renal Physiol. 302: F1-8, 2012. PMC3251344

Chen J, Myerburg MM, Passero CJ, Winarski KL, Sheng S. External Cu2+ inhibits human epithelial Na+ channels by binding at a subunit interface of extracellular domains. J Biol Chem. 286: 27436-46, 2011. PMC3149337

Needham PG, Mikoluk K, Dhakarwal P, Khadem S, Snyder AC, Subramanya AR, Brodsky JL. The thiazide-sensitive NaCl cotransporter is targeted for chaperone-dependent ER-associated degradation. J Biol Chem. 286:43611-21, 2011. PMC3243568

Mattila PE, Youker RT, Mo D, Bruns JR, Cresawn KO, Hughey RP, Ihrke G, Weisz OA. Multiple biosynthetic trafficking routes for apically secreted proteins in MDCK cells. Traffic. 2012, 13:433-42. PMC3276681.

Kashlan, O.B., B. M. Blobner, Z. Zuzek, M.D. Carattino and T.R. Kleyman. Inhibitory tract traps the epithelial Na+ channel in a low activity conformation. J Biol Chem. 287: 20720-6, 2012. PMC3370254

Butterworth MB, Edinger RS, Silvis MR, Gallo LI, Liang X, Apodaca G, Frizzell RA, Johnson JP. Rab11b regulates the trafficking and recycling of the epithelial sodium channel (ENaC). Am J Physiol Renal Physiol. 302:F581-90, 2012. PMC3353647

Pastor-Soler NM, Hallows KR. AMP-activated protein kinase regulation of kidney tubular transport. Curr Opin Nephrol Hypertens. 21:523-33, 2012. PubMed PMID: 22801443

Mueller GM, Yan W, Copelovitch L, Jarman S, Wang Z, Kinlough CL, Tolino MA, Hughey RP, Kleyman TR, Rubenstein RC. Multiple residues in the distal C terminus of the a-subunit have roles in modulating human epithelial sodium channel activity. Am J Physiol Renal Physiol. 303:F220-8, 2012. PMC3404586

Prakasam HS, Herrington H, Roppolo JR, Jackson EK, Apodaca G. Modulation of Bladder Function by Luminal Adenosine Turnover and A1 Receptor Activation. Am J Physiol Renal Physiol. 303:F279-92, 2012. PMC3404591

King JD Jr, Lee J, Riemen CE, Neumann D, Xiong S, Foskett JK, Mehta A, Muimo R, Hallows KR. Role of binding and nucleoside diphosphate kinase A in the regulation of the cystic fibrosis transmembrane conductance regulator by AMP-activated protein kinase. J Biol Chem. 287: 33389-400, 2012. PMC3460441

Mitra S, Lukianov S, Ruiz WG, Cianciolo Cosentino C, Sanker S, Traub LM, Hukriede NA, Apodaca G. Requirement for a uroplakin 3a-like protein in the development of zebrafish pronephric tubule epithelial cell function, morphogenesis, and polarity. PLoS One. 7(7):e41816, 2012. PMC3404999.

Edinger RS, Bertrand CA, Rondandino C, Apodaca GA, Johnson JP, Butterworth MB. The epithelial sodium channel (ENaC) establishes a trafficking vesicle pool responsible for its regulation. PLoS One. 7(9):e46593, 2012. PMC3460899

Chen, J, Winarski, KL, Myerburg, MM, Pitt, BR, Sheng, S. Probing the structural basis of Zn2+ regulation of the epithelial Na+ channel. J Biol Chem, 287:35598-98, 2012. PMID:22930753 PMC Journal - In Process

Chen, J, Kleyman TR and Sheng S. Gain-of-function variant of the human epithelial sodium channel. Am J. Physiol, 2012. In press. PMC Journal - In Process

Shi, S., Carattino MD and Kleyman TR. Role of the wrist domain in the response of the epithelial sodium channel to external stimuli. J. Biol. Chem. 2012, In press. PMC Journal - In Process

Rbaibi Y, Cui S, Mo D, Carattino M., Rohatji R., Satlin LM, Szalinski CM, Antoszewski LM, Fölsch H, Hukriede, NA, and Weisz OA. OCRL1 modulates cilia length in renal epithelial cells. Traffic, 13:1295-1301, 2012. PMID: 22680056 PMC Journal - In Process

Mo D, Ihrke G, Costa SA, Brilli L, Labilloy A, Halfter W, Cosentino CC, Hukriede NA, Weisz OA. Apical targeting and endocytosis of the sialomucin endolyn are essential for establishment of zebrafish pronephric kidney function. J Cell Sci. 2012. In press. PMID:22976307 PMC Journal - In Process

Carattino MD, Mueller GM, Palmer LG, Frindt G, Rued AC, Hughey RP, Kleyman TR. Prostasin interacts with the epithelial Na+ channel and facilitates cleavage of the γ-subunit by a second protease. Am J Physiol Renal Physiol. 2014 Nov 1;307(9):F1080-7. PubMed PMID: 25209858. PMCID: 4216988

Heidrich E, Carattino MD, Hughey RP, Pilewski JM, Kleyman TR, Myerburg MM. Intracellular Na+ regulates epithelial Na+ channel maturation. J Biol Chem. 2015 May 1;290(18):11569-77. Epub 2015 Mar 12. PMID: 25767115; PMCID: 4416860

Kashlan OB, Blobner BM, Zuzek Z, Tolino M, Kleyman TR. Na+ inhibits the epithelial Na+ channel by binding to a site in an extracellular acidic cleft. J Biol Chem 2015; 290(1):568-76. PMID: 25389295; PMCID: 4281758.

Kleyman, TR and Myerburg MM. Proteases, ENaCs and cystic fibrosis. J Physiol. 2014 Dec 1;592(Pt 23):5145. PubMed PMID: 25448184; PubMed Central PMCID: PMC4262328.

Koral K, Li H, Ganesh N, Birnbaum MJ, Hallows KR, Erkan E. Akt recruits Dab2 to albumin endocytosis in the proximal tubule. Am J Physiol Renal Physiol. 2014 Dec 15;307(12):F1380-9. Epub 2014 Sep 24. PMID: 25253241; PMCID: 4269696

Pastor-Soler NM, Sutton TA, Mang HE, Kinlough CL, Gendler SJ, Madsen CS, Bastacky SI, Ho J, Al-Bataineh MM, Hallows KR, Singh S, Monga SP, Kobayashi H, Haase VH, Hughey RP. Muc1 is Protective during Kidney Ischemia-Reperfusion Injury. Am J Physiol Renal Physiol. 2015 Apr 29:ajprenal.00066.2015. doi: 10.1152/ajprenal.00066.2015. PubMed PMID: 25925251. PMCID: In process

Prakasam HS, Gallo LI, Li H, Ruiz WG, Hallows KR, Apodaca G. A1 adenosine receptor-stimulated exocytosis in bladder umbrella cells requires phosphorylation of ADAM17 Ser-811 and EGF receptor transactivation. Mol Biol Cell. 2014 Nov 15;25(23):3798-812. doi: 10.1091/mbc.E14-03-0818. Epub 2014 Sep 17. PubMed PMID: 25232008; PubMed Central PMCID: PMC4230785.

Raghavan V, Rbaibi R, Pastor-Soler N, Carattino MD, and Weisz OA (2014) Shear stress dependent regulation of apical endocytosis in renal proximal tubule cells mediated by primary cilia. Proc Natl Acad Sci USA.111:8506-8511. PubMed PMID: 24912170; PMCID: PMC4060694.

Ray, E.C., H. Rondon-Berrios, C.R, Boyd and T.R. Kleyman. Mechanisms of sodium retention and volume expansion in nephrotic syndrome: implications for hypertension. Adv. Chronic Kidney Dis. 22:179-184, 2015. PMID: 25908466; PMCID: PMC4409655

Ray, E.C. and T.R. Kleyman. Cutting it out: ENaC processing in the human nephron. J. Am. Soc. Nephrol. 26:1-3, 2015. PubMed PMID: 25060054; PubMed Central PMCID: PMC4279749.

Roy A, Goodman JH, Begum G, Donnelly BF, Pittman G, Weinman EJ, Sun D, Subramanya AR. Generation of WNK1 knockout cell lines by CRISPR/Cas-mediated genome editing. Am J Physiol Renal Physiol. 2015 Feb 15;308(4):F366-76. doi: 10.1152/ajprenal.00612.2014. Epub 2014 Dec 4. PubMed PMID: 25477473; PubMed Central PMCID: PMC4329490.

Roy A, Al-Bataineh MM, Pastor-Soler NM. Collecting duct intercalated cell function and regulation. Clin J Am Soc Nephrol. 2015 Feb 6;10(2):305-24. doi: 10.2215/CJN.08880914. Epub 2015 Jan 28. PubMed PMID: 25632105; PubMed Central PMCID: PMC4317747.

Priedigkeit NM, Wolfe NW, Clark NL. Evolutionary signatures amongst disease genes permit novel methods for gene prioritization and construction of informative gene networks. PLOS Genetics. 2015; 11(2): e1004967. PMCID PMC4334549.


Enter the name for this tabbed section: Single Nephron & Metabolomics
Ren J, Mi Z, Stewart N, and Jackson EK. Identification and quantification of 2’,3’-cAMP release by the kidney. Journal of Pharmacology and Experimental Therapeutics. 328: 855-865, 2009. PMC2646794

Sun P, Liu W, Lin DH, Yue P, Kemp R, Satlin LM, and Wang WH. Epoxyeicosatrienoic acid activates BK channels in the cortical collecting duct. J. Am. Soc. Nephrol. 20:513-23, 2009. PMC2653685

Rajakariar R, Newson J, Jackson EK, Sawmynaden P, Smith A, Rahman F, Yaqoob MM, and Gilroy DW. Non-resolving inflammation in gp91phox-/- mice, a model of human chronic granulomatous disease has lower adenosine and cAMP. Journal of Immunology. 182: 3262-3269, 2009. PMC2692062

Jackson EK, and Mi Z. Regulation of renovascular 3’,5’-cAMP in spontaneously hypertensive rats. Hypertension. 54: 270-277, 2009. PMC275526

Jackson EK, Ren J, and Mi Z. Extracellular 2’,3’-cAMP is a source of adenosine. Journal of Biological Chemistry. 284, 33097-33106, 2009. PMC2785151

Liu W, Wei Y, Sun P, Wang WH, Kleyman TR, and Satlin LM.: Mechanoregulation of BK channel activity in the mammalian cortical collecting duct (CCD): role of protein kinases A and C. Am. J. Physiol. Renal Physiol. 297:F904-15, 2009. PMC2775580

Mandapathil M, Hildorfer B, Szczepanski MJ, Czyatowaka M, Szajnik M, Ren J, Lang S, Jackson EK, Gorelik E, and Whiteside TL. Generation and accumulation of immunosuppressive adenosine by human CD4+CD25highFoxp3+ regulatory T cells (TREG). Journal of Biological Chemistry. 285: 7176-7186, 2010. PMC2844167

Dubey RK, Rosselli M, Gillespie DG, Mi Z, and Jackson EK. Extracellular 3’,5’-cAMP-adenosine pathway inhibits glomerular mesangial cell growth. Journal of Pharmacology and Experimental Therapeutics. 333: 808-815, 2010. PMC2879927

Jackson EK, Ren J, Gillespie DG, and Dubey RK. Extracellular 2’,3’-cAMP is a potent inhibitor of preglomerular vascular smooth muscle cell and mesangial cell growth. Hypertension. 56: 151-158, 2010. PMC2892387

Dubey RK, Jackson EK, Gillespie DG, Zacharia LC, Imthurn B, and Rosselli M. Resveratrol blocks the antimitogenic effects of estradiol on human female aortic smooth muscle cells. Journal of Clinical Endocrinology and Metabolism. 95: E9-E17, 2010. PMC2936070

Baruscotti I, Barchiesi F, Jackson EK, Imthurm B, Stiller R, Schaufelberger S, Rosselli M, and Dubey R.K. Estradiol stimulates capillary formation by human endothelial cells: Role of ER-/, heme oxygenase-1 and tyrosine kinase. Hypertension. 56: 397-404, 2010. PMC2936691

Mandapathil M, Szczepanski MJ, Szajnik M, Ren J, Jackson EK, Johnson JT, Gorelik E, Lang S, and Whiteside TL. Adenosine and prostaglandin E2 cooperate in the suppression of immune responses mediated by adaptive regulatory T cells. Journal of Biological Chemistry. 285: 27571-27580, 2010. PMC2934624

Barchiesi F, Lucchinetti E, Zaugg M, Ogunshola OO, Wright M, Meyer M, Rosselli M, Gillespie DG, Jackson EK, and Dubey RK. Candidate genes for 2-methoxyestradiol-mediated vasoprotective actions in human aortic smooth muscle cells. Hypertension. 56: 964-972, 2010. PMC3023414

Cheng D, Ren J, and Jackson EK. Multidrug resistance protein 4 mediates 3’,5’-cAMP efflux from rat preglomerular vascular smooth muscle cells. Clinical and Experimental Pharmacology and Physiology. 37: 205-207, 2010. PMC3068533

Tofovic DS, Bilan VP, and Jackson EK. Sitagliptin augments angiotensin II-induced renal vasoconstriction in kidneys from rats with the metabolic syndrome. Clinical and Experimental Pharmacology and Physiology. 37: 689-691, 2010. PMC3069484

Cheng D, Ren J, Gillespie DG, Mi Z, and Jackson EK. Regulation of 3’,5’-cAMP in preglomerular smooth muscle and endothelial cells from genetically-hypertensive rats. Hypertension. 56: 1096-1101, 2010. PMC3011225

Carrisoza-Gaytán R, Salvador C, Satlin L, Liu W, Zavilowitz B, Bobadilla NA, Trujillo J and Escobar LI: Potassium secretion by the voltage gated potassium channel Kv1.3 in the rat kidney. Am J Physiol Renal Physiol. 299:F255-64, 2010. PMC2904170

Weinbaum S, Duan Y, Satlin LM, Wang T, and Weinstein A. Mechanotransduction in the renal tubule. Am J Physiol Renal Physiol. 299:F1220-36, 2010. PMC3006307
Jackson EK. The 2’,3’-Cyclic-AMP-adenosine pathway. Am. J. Physiol. Renal Physiol. 301, F1160F1167 2011. PMC3166383

Battula S, Hao S, Pedraza PI, Stier CT, and Ferreri NR. Tumor necrosis factor-a is an endogenous inhibitor of Na-K-2Cl cotransporter (NKCC2) isoform A in the thick ascending limb. Am. J. Physiol. Renal Physiol. 301: F94-F100, 2011. PMC3129887

Su Y, Jackson EK, and Gorelik E. Receptor desensitization and blockade of the suppressive effects of adenosine and prostaglandin E2 (PGE2) on the cytotoxic activity of human melanoma-infiltrating T lymphocytes. Cancer Immunology and Immunotherapy. 60: 111-122, 2011. PMC3107516

Jackson EK, Gillespie DG, and Dubey RK. 2’-AMP and 3’-AMP inhibit proliferation of preglomerular vascular smooth muscle cells and glomerular mesangial cell growth via A2B receptors. Journal of Pharmacology and Experimental Therapeutics 337: 444-450, 2011. PMC3083111

Jackson EK, Ren J, and Gillespie DG. 2’,3’-cAMP, 3’-AMP and 2’-AMP inhibit human aortic and coronary vascular smooth muscle cell proliferation via A2B receptors. American Journal of Physiology: Heart and Circulatory Physiology. 301: H391-H401, 2011. PMC3154660

Verrier JD, Exo JL, Jackson TC, Ren J, Gillespie, DG, Dubey RK, Kochanek, PM, and Jackson EK. Expression of the 2’,3’-cAMP-adenosine pathway in astrocytes and microglia. Journal of Neurochemistry. 118: 979-987, 2011. PMC3166383

Jackson EK, Ren J, Cheng D, and Gillespie DG. Extracellular cAMP-adenosine pathways in the mouse kidney. Am. J. Physiol. Renal Physiol. 301: F565-F573, 2011. PMC3174555

Liu W, Schreck C, Coleman RA, Wade JB, Hernandez Y, Zavilowitz B, Warth R, Kleyman TR, and Satlin LM. Role of NKCC1 in BK channel-mediated net K secretion in the CCD. Am. J. Physiol. Renal Physiol. 301:F1088-97, 2011. PMC3280697

Bhave G, Chauder BA, Liu W, Dawson ES, Kadakia R, Nguyen TT, Lewis LM, Meiler J, Weaver CD, Satlin LM, Lindsley CW, and Denton JS. Development of a selective small-molecule inhibitor of Kir1.1, the Renal Outer Medullary Potassium Channel. Mol Pharmacol. 79:42-50, 2011. PMC3014278

Carrisoza-Gaytán R, Saldaña-Meyer R, Rangel C, Salvador C, Escalona C, Satlin L, Liu W, Zavilowitz B, Trujillo J, Bobadilla N, and Escobar LI. The hyperpolarization-activated cyclic nucleotide-gated HCN2 channel transports ammonium in the distal nephron. Kidney Int. 80:832-40, 2011. PMID: 21796099

Cheng D, Zhu X, Barchiesi F, Gillespie DG, Dubey RK, and Jackson EK. RACK1 regulates cell proliferation by modulating calcium signaling. Hypertension. 58: 689-695, 2011. PMC3174333

Jackson EK, Cheng D, Tofovic SP, and Mi Z. Endogenous adenosine contributes to renal sympathetic neurotransmission via postjunctional A1-receptor-mediated coincident signaling. Am. J. Physiol. Renal Physiol. 302: F466-FF76, 2012. PMC3289416

Olteanu D, Liu X, Liu W, Roper VC, Sharma N, Yoder BK, Satlin LM, Schwiebert EM, and Bevensee MO. Increased Na+-H+ exchanger activity on the apical surface of a cilium-deficient cortical collecting duct principal cell model of polycystic kidney disease. Am J Physiol Cell Physiol. 302:C1436-51, 2012. PMC3361997

Liu W, Pastor-Soler NM, Schreck C, Zavilowitz B, Kleyman TR, Satlin LM. Luminal flow modulates H+-ATPase activity in the cortical collecting duct (CCD). Am J Physiol Renal Physiol. 302:F205-15, 2012. PMC3251342.

Verrier JD, Jackson TC, Kochanek, PM, and Jackson EK. The brain in vivo expresses the 2’,3’-cAMP-adenosine pathway. Journal of Neurochemistry. 122: 115-125, 2012. PMC3371318

Zhang L, Franchini M, Eser MW, Jackson EK, and Dip R. Increased adenosine concentration in bronchoalveolar lavage fluid of horses with lower airway inflammation. The Veterinary Journal 193:268-70, 2012. PMID:22206730

Flores D, Liu Y, Liu W, Satlin LM, and Rohatgi R. Flow induced prostaglandin E2 release regulates Na and K transport in the collecting duct. Am J Physiol Renal Physiol. 303:F632-8, 2012. PMID: 22696602 PMC Journal-in Process

Mandapathil M, Szczepanski M, Harasymczuk M, Ren J, Cheng D, Jackson EK, Gorelik E, Jonas T, Johnson JT, Lang S, and Whiteside TL. CD26 expression and adenosine deaminase activity in regulatory T cells (Treg) and CD4+ T effector cells in patients with head and neck squamous cell carcinoma. OncoImmunology 1:659-669, 2012. PMC3429570

Prakasam HS, Herrington H, Roppollo J, Jackson EK, and Apodaca G. Modulation of bladder function by adenosine turnover and A1 receptor activation. Am. J. Physiol. Renal Physiol. 303:F279-92, 2012. PMC3404591

Jackson EK, Kochanek SJ, and Gillespie DG. Dipeptidyl peptidase IV regulates proliferation of preglomerular vascular smooth muscle and mesangial cells. Hypertension. 60:757-64, 2012. PMC3422672

Rbaibi Y, Cui S, Mo D, Carattino M., Rohatji R., Satlin LM, Szalinski CM, Antoszewski LM, Fölsch H, Hukriede, NA, and Weisz OA (2012) OCRL1 modulates cilia length in renal epithelial cells. Traffic, 13:1295-1301, 2012. PMID: 22680056 PMC Journal - In Process

Carrisoza-Gaytán R., Liu Y., Flores D., Else D., Lee H.G., Rhodes G., Sandoval R., Kleyman T., Lee F., Molitoris B., Satlin L.M.*, and R. Rohatgi*. Effects of biomechanical forces on signaling in the cortical collecting duct (CCD). Am J Physiol Renal Physiol 307:F195-204, 2014. (*, contributed equally to this work) PMID:24872319 PMCID:PMC4152160

Chang, A., Yeung, S., Thakkar,A. Kevin M. Huang, K.M., Liu, M.M., Rhye-Samuel Kanassatega, R.S., Parsa, C. Orlando, R., Jackson, E.K., Bradley T. Andresen, B.T., and Huang, Y.: Prevention of skin carcinogenesis by the -blocker carvedilol. Cancer Prevention Research 8:27-36, 2015. PMID:25367979 PMCID:PMC4289657

Hatfield, S.M., Kjaergaard, J., Lukashev, D., Belikoff, B., Schreiber, T.H., Sethumadhavan, S., Abbott, R., Philbrook, P., Thayer, M., Shujia, D., Rodig, S., Kutok, J.L., Ren, J., Ohta, A., Podack, E.R., Karger, B., Jackson, E.K., and Sitkovsky, M. Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection. Journal of Molecular Medicine 92: 1283-1292, 2014. PMC4247798

Hatfield, S.M., Kjaergaard, J., Lukashev, D., Schreiber, T.H., Belikoff, B., Abbott, R., Sethumadhavan, S., Philbrook, P., Ko, K., Cannici, R., Thayer, M., Rodig, S., Kutok, J.L., Jackson, E.K., Karger, B., Podack, E.R., Ohta, A., and Sitkovsky, M: Immunological mechanisms of the anti-tumor effects of supplemental oxygenation. Science Translational Medicine. 2015, In press.

Jackson, E.K., Cheng, D., Mi, Z., and Gillespie, D.G.: Guanosine regulates adenosine levels in the kidney. Physiological Reports 2, e12028, 2014. PMC4098751

Jackson, E.K., Cheng, D., Verrier, J.D., Janesko-Feldman, K., and Kochanek, P.M.: Interactive roles of CD73 and tissue non-specific alkaline phosphatase in the renal vascular metabolism of 5’-AMP. American Journal of Physiology Renal Physiology 307: F680-F685, 2014. PMCID:PMC4166734

Jackson, E.K., Gillespie, D.G., Mi, Z., Cheng, D., Bansal, R., Janesko-Feldman, K., and Kochanek, P.M.: Role of 2’,3’-cyclic nucleotide 3’-phosphodiesterase in the renal 2’,3’-cAMP-adenosine pathway. American Journal of Physiology Renal Physiology 307: F14-F24, 2014. PMCID:PMC4080157

Jackson, E.K., and Mi, Z.: The guanosine-adenosine interaction exists in vivo. Journal of Pharmacology and Experimental Therapeutics 350: 719-726, 2014. PMCID:PMC4152880

Jackson, E.K., Mi, Z., Tofovic, S.P., and Gillespie, D.G.: Effect of dipeptidyl peptidase 4 inhibition on arterial blood pressure is context dependent. Hypertension 65: 238-249, 2015. PMCID:PMC4268428

Miller, R.L., Denny, G.O., Knuepfer, M.M., Kleyman, R.R., Jackson, E.K., Salkoff, L.B., and Loewy, A.D.: Blockade of ENaCs by amiloride induces c-Fos activation of the area postrema. Brain Research. 1601: 40-51, 2015. PMC4346418

Newell, E.A., Exo, J.L., Verrier, J.D., Jackson, T.C., Gillespie, D.G., Janesko-Feldman, K., Kochanek, P.M., and Jackson , E.K.: 2',3'-cAMP, 3'-AMP, 2'-AMP and adenosine inhibit TNF-α and CXCL10 production from activated primary murine microglia via A2A receptors. Brain Research 1594: 27-35, 2015. PMCID:PMC4262711

Schuler, P.J., Saze, Z, Hong, C-S., Muller, L., Gillespie, D.G., Cheng, D., Harasymczuk, M., Mandapathil, M., Lang, S., Jackson, E.K., and Whiteside, T.L.: Human CD4+CD39+ regulatory T cells produce adenosine upon co-expression of surface CD73 or contact with CD73+ exosomes or CD73+ cells. Clinical & Experimental Immunology 177: 531-543, 2014. PMCID:PMC4226604

Wei Y., Liao Y., Zavilowitz B., Ren J., Liu W., Chan P., Rohatgi R., Estilo G., Jackson E.K., Wang W., and L.M. Satlin. Angiotensin type 2 receptor regulates ROMK-like K channel activity in renal cortical collecting duct during high dietary potassium adaptation. Am J Physiol Renal Physiol 307:F833-43, 2014. PMID: 25100281 PMCID:PMC4187043


Enter the name for this tabbed section: Kidney Imaging
Khandelwal P, Ruiz WG, Balestreire-Hawryluk E, Weisz OA, Goldenring JR, Apodaca G. Rab 11a dependent exocytosis of discoidal/fusiform vesicles in bladder umbrella cells. Proc Natl Acad Sci U S A. 105:15773-8, 2008. PMC257297

Yu W, Khandelwal P, Apodaca G. Distinct apical and basolateral membrane requirements for stretch-induced membrane traffic at the apical surface of bladder umbrella cells. Mol Biol Cell. 20:282-95, 2009. PMC2613117

Hallows KR, Wang H, Edinger RS, Butterworth MB, Oyster NM, Lil H, Buck J, Levin LR, Johnson JP, Pastor-Soler N. Novel regulation of epithelial Na+ transport by soluble adenlyl cyclase in kidney collecting duct cells. J Biol Chem. 284:5774-83, 2009. PMC2645828

Hallows KR, Alzamora R, Li H, Gong F, Smolak C, Neumann D, Pastor-Soler NM. AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells. Am J Physiol Cell Physiol. 296:C672-81, 2009. PMC2670645

Edeling MA, Sanker S, Shima T, Umasankar PK, Höning S, Kim HY, Davidson LA, Watkins SC, Tsang M, Owen DJ, Traub LM. Structural requirements for PACSIN/Syndapin operation during zebrafish embryonic notochord development. PLoS One 4:e8150, 2009. PMC2780292.

Fölsch H, Mattila PE, and Weisz OA. Taking the scenic route: Biosynthetic traffic to the plasma membrane in polarized epithelial cells. Traffic. 10:972-981, 2009. PMC2786770

Khandelwal P, Abraham SN, Apodaca G. Cell biology and physiology of the uroepithelium. Am J Physiol Renal Physiol. 297:F1477-501, 2009. PMC2801337.

Mattila, P.E., Kinlough, C.L., Bruns, J.R., Weisz, O.A., and Hughey, R.P. MUC1 traverses apical recycling endosomes along the biosynthetic pathway in polarized MDCK cells. Biol Chem., 390:551-6, 2009. PMID: 19453277

Cui S, Guerriero CJ, Szalinski CM, Kinlough CL, Hughey RP, Weisz OA. OCRL1 function in renal epithelial membrane traffic. Am J Physiol Renal Physiol. 298:F335-45, 2010. PMC2822509.

Vogt, A, Cholewinski, A, Shen, X, Nelson, S, Lazo, JS, Tsang, M and Hukriede NA. Automated image-based phenotypic analysis in zebrafish embryos. Dev. Dynamics. 238:656-663, 2009. PMC2861575

de Groh ED, Swanhart LM, Cianciolo Cosentino C, Jackson RL, Dai W, Kitchens CA, Day BW, Smithgall TE and Hukriede NA. Inhibition of Histone Deacetylase Expands the Renal Progenitor Cell Population. J. Amer. Soc. Nephrology. 21:794-802, 2010. PMC2865739

Swanhart LM, Takahashi N, Jackson RL, Gibson GA, Watkins SC, Dawid IB and Hukriede NA. Generation of an lhx1a transgenic reporter in zebrafish. Int. J. Dev. Biol. 54:721-736, 2010. PMC2880469

Myerburg, MM, King, JD, Oyster, NM, Fitch, AC, Magill, A, Baty, CJ, Watkins, SC, Kolls, JK, Pilewski, JM, Hallows, KR. AMPK agonists ameliorate sodium and fluid transport and inflammation in CF airway epithelial cells. Am J Respir Cell Mol Biol. 42: 676-84, 2010. PMC2891496

Li, H, Thali, RF, Smolak, C, Gong, F, Alzamora, R, Wallimann, T, Scholz, R, Pastor-Soler, NM, Neumann, D, Hallows, KR. Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells. Am J Physiol Renal Physiol. 299: F167-77, 2010. PMC2904179

Pedersen GA, Chakraborty S, Steinhauser AL, Traub LM, Madsen M. AMN Directs Endocytosis of the Intrinsic Factor-Vitamin B Receptor Cubam by Engaging ARH or Dab2. Traffic. 11:706-720. 2010.: PMC2964065

Gong F, Alzamora R, Smolak C, Li H, Naveed S, Neumann D, Hallows KR, Pastor-Soler NM. Vacuolar H+-ATPase apical accumulation in kidney intercalated cells is regulated by PKS and AMP-activated protein kinase. Am J Physiol Renal Physiol. 298:F1162-R1169. 2010. PMC2867405

Khandelwal P, Ruiz WG, Apodaca G. Compensatory endocytosis in bladder umbrella cells occurs through an integrin-regulated and RhoA- and dynamin-dependent pathway. EMBO J. 29:1961-75, 2010. PMC2892371

Alzamora R, Thali RF, Gong F, Smolak C, Li H, Baty CJ, Bertrand CA, Auchli Y, Brunisholz RA, Neumann D, Hallows KR, Pastor-Soler NM. PKA regulates vacuolar H+-ATPase localization and activity via direct phosphorylation of the subunit in kidney cells. J Biol Chem. 285:24676-85, 2010. PMC2915704

Mo D, Potter BA, Bertrand CA, Hildebrand JD, Bruns JR, and Weisz, OA. Nucleofection disrupts tight junction fence function to alter membrane polarity of renal epithelial cells. Am J Physiol Renal Physiol. 299: F1178-84, 2010. PMC2980404

Alzamora R, Gong F, Rondanino C, Lee JK, Smolak C, Pastor-Soler NM, Hallows KR. AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells. Am J Physiol Renal Physiol. 299:F1308-19, 2010. PMC3006313

Yu W, Hill WG, Apodaca G, Zeidel ML. Expression and distribution of transient receptor potential (TRP) channels in bladder epithelium. Am J Physiol Renal Physiol. 300:F49-59, 2011. PMC3023226

Tran JR, Tomsic LR, Brodsky JL. A Cdc48p-associated factor modulates endoplasmic reticulum-associated degradation, cell stress, and ubiquitinated protein homeostasis. J Biol Chem. 286:5744-55, 2011. PMC3037687

Cirio MC, Zhao H, Haldin CE, Cianciolo Cosentino C, Stuckenholz C. Chen X, Hong SK, Dawid IB and Hukriede NA. Lhx1 is required for specification of the renal progenitor cell field. PLoS One 6:e18858, 2011. PMC3078140

Cianciolo Cosenitino C, Roman BL, Drummond IA, and Hukriede NA. Intravenous microinjections of zebrafish larvae to study acute kidney injury. J Vis Exp. 42:pii: 2079, 2010. PMC3156013

Diep, CQ, Ma D, Arora N, Wingert RA, Bollig F, Djordjevic G, Lichman B, Zhu H, Ikenaga T, Ono F, Englert C, Hukriede NA, Handin RI, and Davidson AJ. Identification of adult renal progenitor cells capable of nephron formation and regeneration in zebrafish. Nature. 470:95-100, 2011. PMC3170921

Rondanino C, Poland PA, Kinlough CL, Li H, Rbaibi Y, Myerburg MM, Al-Bataineh MM, Kashlan OB, Pastor-Soler NM, Hallows KR, Weisz OA, Apodaca G, Hughey RP. Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells. Am J Physiol Renal Physiol. 2011, 301:F622-33. PMC3174547

Kinlough CL, Poland PA, Gendler SJ, Mattila PE, Mo D, Weisz OA, Hughey RP. Core-glycosylated mucin-like repeats from MUC1 are an apical targeting signal. J Biol Chem. 2011, 286:39072-81. PMC3234732.

Liu W, Pastor-Soler NM, Schreck C, Zavilowitz B, Kleyman TR, Satlin LM. Luminal flow modulates H+-ATPase activity in the cortical collecting duct (CCD). Am J Physiol Renal Physiol. 2012, 302:F205-15. PMC3251342.

Mattila PE, Youker RT, Mo D, Bruns JR, Cresawn KO, Hughey RP, Ihrke G, Weisz OA. Multiple biosynthetic trafficking routes for apically secreted proteins in MDCK cells. Traffic. 2012, 13:433-42. PMC3276681.

Grubb S, Guo L, Fisher EA, Brodsky JL. Protein disulfide isomerases contribute differentially to the endoplasmic reticulum-associated degradation of apolipoprotein B and other substrates. Mol Biol Cell. 23(4):520-32, 2012. PMC3279382

Liu W, Schreck C, Coleman RA, Wade JB, Hernandez Y, Zavilowitz B, Warth R, Kleyman TR, and Satlin LM. Role of NKCC1 in BK channel-mediated net K secretion in the CCD. Am. J. Physiol. Renal Physiol. 301:F1088-97, 2011. PMC3280697

Butterworth MB, Edinger RS, Silvis MR, Gallo LI, Liang X, Apodaca G, Frizzell RA, Johnson JP. Rab11b regulates the trafficking and recycling of the epithelial sodium channel (ENaC). Am J Physiol Renal Physiol. 302:F581-90, 2012. PMC3353647

Prakasam HS, Herrington H, Roppolo JR, Jackson EK, Apodaca G. Modulation of Bladder Function by Luminal Adenosine Turnover and A1 Receptor Activation. Am J Physiol Renal Physiol. 303:F279-92, 2012. PMC3404591

Mitra S, Lukianov S, Ruiz WG, Cianciolo Cosentino C, Sanker S, Traub LM, Hukriede NA, Apodaca G. Requirement for a uroplakin 3a-like protein in the development of zebrafish pronephric tubule epithelial cell function, morphogenesis, and polarity. PLoS One. 7(7):e41816, 2012. PMC3404999.

Edinger RS, Bertrand CA, Rondandino C, Apodaca GA, Johnson JP, Butterworth MB. The epithelial sodium channel (ENaC) establishes a trafficking vesicle pool responsible for its regulation. PLoS One. 7(9):e46593, 2012. PMC3460899

Rbaibi Y, Cui S, Mo D, Carattino M., Rohatji R., Satlin LM, Szalinski CM, Antoszewski LM, Fölsch H, Hukriede, NA, and Weisz OA (2012) OCRL1 modulates cilia length in renal epithelial cells. Traffic, 13:1295-1301, 2012. PMID: 22680056 PMC Journal - In Process

Mo D, Ihrke G, Costa SA, Brilli L, Labilloy A, Halfter W, Cosentino CC, Hukriede NA, Weisz OA. Apical targeting and endocytosis of the sialomucin endolyn are essential for establishment of zebrafish pronephric kidney function. J Cell Sci. 2012 - in press. PMID:22976307 PMC Journal - In Process

Gelling CL, Dawes IW, Perlmutter DH, Fisher EA, Brodsky JL. The Endosomal Protein Sorting Receptor Sortilin Has a Role in Trafficking alpha-1 Antitrypsin. Genetics. 2012 - In press. PMID: 22923381 PMC Journal - In Process

Hanna-Mitchell AT, Ruiz GW, Daneshgari F, Liu G, Apodaca G, Birder LA. Am J Physiol Regul Integr Comp Physiol. 2012 - in press PMID: 23174855 PMC Journal - In Process

Apodaca G, Brown WJ. Membrane traffic research: challenges for the next decade. Front Cell Dev Biol. 2014 Sep 17;2:52. doi: 10.3389/fcell.2014.00052. eCollection 2014. PubMed PMID: 25364759; PubMed Central PMCID: PMC4207031

Chiba, T, Skrypnyk, N., Brilli, L, Penchey, R., Zhang, K.X., Rochon, E.R., Fall, J.L., Paueksakon, P., Yang, H., Roman, B.L., Zhang, M-Z., Harris, R., Hukriede, N.A., and M.P. de Caestecker (2015) Retinoic Acid Signaling Coordinates Macrophage-Dependent Injury and Repair after Acute Kidney Injury. JASN In press.

Di Giovanni V, Walker KA, Bushnell D, Schaefer C, Sims-Lucas S, Puri P, Bates CM. Fibroblast growth factor receptor-Frs2α signaling is critical for nephron progenitors. Dev Biol. 2015 Apr 1;400(1):82-93. doi: 10.1016/j.ydbio.2015.01.018. Epub 2015 Jan 30. PubMed PMID: 25641696; PubMed Central PMCID: PMC4361332.

Gallo LI, Liao Y, Ruiz WG, Clayton DR, Li M, Liu YJ, Jiang Y, Fukuda M, Apodaca G, Yin XM. TBC1D9B functions as a GTPase-activating protein for Rab11a in polarized MDCK cells. Mol Biol Cell. 2014 Nov 15;25(23):3779-97. doi: 10.1091/mbc.E13-10-0604. Epub 2014 Sep 17. PubMed PMID: 25232007; PubMed Central PMCID: PMC4230784.

Gidon A, Al-Bataineh MM, Jean-Alphonse FG, Stevenson HP, Watanabe T, Louet C, Khatri A, Calero G, Pastor-Soler NM, Gardella TJ, Vilardaga JP. Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase. Nat Chem Biol. 2014 Sep;10(9):707-9. doi: 10.1038/nchembio.1589. Epub 2014 Jul 27. PubMed PMID: 25064832; PubMed Central PMCID: PMC4138287

Pastor-Soler NM, Sutton TA, Mang HE, Kinlough CL, Gendler SJ, Madsen CS, Bastacky SI, Ho J, Al-Bataineh MM, Hallows KR, Singh S, Monga SP, Kobayashi H, Haase VH, Hughey RP. Muc1 is Protective during Kidney Ischemia-Reperfusion Injury. Am J Physiol Renal Physiol. 2015 Apr 29:ajprenal.00066.2015. doi: 10.1152/ajprenal.00066.2015. PubMed PMID: 25925251. PMCID: In process

Prakasam HS, Gallo LI, Li H, Ruiz WG, Hallows KR, Apodaca G. A1 adenosine receptor-stimulated exocytosis in bladder umbrella cells requires phosphorylation of ADAM17 Ser-811 and EGF receptor transactivation. Mol Biol Cell. 2014 Nov 15;25(23):3798-812. doi: 10.1091/mbc.E14-03-0818. Epub 2014 Sep 17. PubMed PMID: 25232008; PubMed Central PMCID: PMC4230785.

Raghavan V, Rbaibi R, Pastor-Soler N, Carattino MD, and Weisz OA (2014) Shear stress dependent regulation of apical endocytosis in renal proximal tubule cells mediated by primary cilia. Proc Natl Acad Sci USA.111:8506-8511. PubMed PMID: 24912170; PMCID: PMC4060694.

Tan RJ, Zhou D, Xiao L, Zhou L, Li Y, Bastacky SI, Oury TD, Liu Y. Extracellular Superoxide Dismutase Protects against Proteinuric Kidney Disease. J Am Soc Nephrol. 2015 Feb 2. pii: JASN.2014060613. [Epub ahead of print] PubMed PMID: 25644107. PMCID: In process

Walker KA, Ikeda Y, Zabbarova I, Schaefer CM, Bushnell D, De Groat WC, Kanai A, Bates CM. Fgfr2 is integral for bladder mesenchyme patterning and function. Am
J Physiol Renal Physiol. 2015 Apr 15;308(8):F888-98. doi: 10.1152/ajprenal.00624.2014. Epub 2015 Feb 4. PubMed PMID: 25656370. PubMed Central PMCID: PMC4398839.


Enter the name for this tabbed section: Model Organisms
Wright CM, Seguin SP, Fewell SW, Zhang H, Ishwad C, Vats A, C Lingwood CA, Wipf P, Fanning E, Pipas JM, and Brodsky JL. Inhibition of Simian Virus 40 Replication by Targeting the Molecular Chaperone Function and ATPase Activity of T Antigen. Virus Res. 141:71-80, 2009.PMC2758074

Vogt, A, Cholewinski, A, Shen, X, Nelson, S, Lazo, JS, Tsang, M and Hukriede NA. Automated image-based phenotypic analysis in zebrafish embryos. Dev. Dynamics. 238:656-663, 2009. PMC2861575

Swanhart LM, Takahashi N, Jackson RL, Gibson GA, Watkins SC, Dawid IB and Hukriede NA. Generation of an lhx1a transgenic reporter in zebrafish. Int. J. Dev. Biol. 54:721-736, 2010. PMC2880469

Buck TM, Kolb AR, Boyd CR, Kleyman TR, and Brodsky JL. The endoplasmic reticulum-associated degradation of the epithelial sodium channel requires a unique complement of molecular chaperones. Mol Biol Cell. 21:1047-58, 2010. PMC2836957

de Groh ED, Swanhart LM, Cianciolo Cosentino C, Jackson RL, Dai W, Kitchens CA, Day BW, Smithgall TE and Hukriede NA. Inhibition of Histone Deacetylase Expands the Renal Progenitor Cell Population. J. Amer. Soc. Nephrology. 21:794-802, 2010. PMC2865739

Cianciolo Cosenitino C, Roman BL, Drummond IA, and Hukriede NA. Intravenous microinjections of zebrafish larvae to study acute kidney injury. J Vis Exp. 42:pii: 2079, 2010. PMC3156013

Patterson ST, Reithmeier RA. Cell surface rescue of kidney anion exchanger 1 mutants by disruption of chaperone interactions. J Biol Chem. 285:33423-34, 2010. PMC2963362

Goeckeler JL, Brodsky JL. Molecular chaperones and substrate ubiquitination control the efficiency of endoplasmic reticulum-associated degradation. Diabetes Obes Metab.12 Suppl 2:32-8, 2010. PMC3071497

Huryn DM, Brodsky JL, Brummond KM, Chambers PG, Eyer B, Ireland AW, Kawasumi M, Laporte MG, Lloyd K, Manteau B, Nghiem P, Quade B, Seguin SP, Wipf P. Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators. Proc Natl Acad Sci U S A. 108:6757-62, 2011. PMC3084104

Kolb AR, Buck TM, Brodsky JL. Saccharomyces cerivisiae as a model system for kidney disease: What can yeast tell us about renal function? Am J Physiol Renal Physiol. 301:F1-11, 2011. PMC3129885

Yi SX, Benoit JB, Elnitsky MA, Kaufmann N, Brodsky JL, Zeidel ML, Denlinger DL, Lee RE Jr. Function and immuno-localization of aquaporins in the Antarctic midge Belgica antarctica. J Insect Physiol. 57:1096-105, 2011. PMID 21315725

Tran JR, Tomsic LR, Brodsky JL. A Cdc48p-associated factor modulates endoplasmic reticulum-associated degradation, cell stress, and ubiquitinated protein homeostasis. J Biol Chem. 286:5744-55, 2011. PMC3037687

Botha M, Chiang AN, Needham PG, Stephens LL, Hoppe HC, Külzer S, Przyborski JM, Lingelbach K, Wipf P, Brodsky JL, Shonhai A, Blatch GL. Plasmodium falciparum encodes a single cytosolic type I Hsp40 that functionally interacts with Hsp70 and is upregulated by heat shock. Cell Stress Chaperones. 16:389-401, 2011. PMC3118825

Ahn JH, Luo W, Kim J, Rodina A, Clement CC, Aguirre J, Sun W, Kang Y, Maharaj R, Moulick K, Zatorska D, Kokoszka M, Brodsky JL, Chiosis G. Design of a Flexible Cell-Based Assay for the Evaluation of Heat Shock Protein 70 Expression Modulators. Assay Drug Dev Technol. 9:236-46, 2011. PMC3102259

Diep, CQ, Ma D, Arora N, Wingert RA, Bollig F, Djordjevic G, Lichman B, Zhu H, Ikenaga T, Ono F, Englert C, Hukriede NA, Handin RI, and Davidson AJ. Identification of adult renal progenitor cells capable of nephron formation and regeneration in zebrafish. Nature. 470:95-100, 2011. PMC3170921

Vollmer LL, Jimenez M, Camarco DP, Zhu W, Daghestani HN, Balachandran R, Reese CE, Lazo JS, Hukriede NA, Curran DP, Day BW, and Vogt A. A simplified synthesis of novel dictyostatin analogs with in vitro activity against epothilone B resistant cells and antiangiogenic activity in zebrafish embryos. Mol Cancer Ther. 10:994-1006, 2011. PMC3112307

Brodsky, JL and Skach, WR. Protein folding and quality control in the endoplasmic reticulum: Recent lessons from mammalian and yeast systems. Curr. Opin. Cell Biol. 4:464-75, 2011. PMC3154734

Needham PG, Mikoluk K, Dhakarwal P, Khadem S, Snyder AC, Subramanya AR, Brodsky JL. The thiazide-sensitive NaCl cotransporter is targeted for chaperone-dependent ER-associated degradation. J Biol Chem. 286:43611-21, 2011. PMC3243568

Cirio MC, Zhao H, Haldin CE, Cianciolo Cosentino C, Stuckenholz C. Chen X, Hong SK, Dawid IB and Hukriede NA. Lhx1 is required for specification of the renal progenitor cell field. PLoS One 6:e18858, 2011. PMC3078140

Swanhart LM, Cianciolo Cosentino C, Diep CQ, Davidson AJ, de Caestecker M, and Hukriede NA. Zebrafish Kidney Development: Basic Science to Translation Research. Birth Defects Res. C Embryo Today. 93:141-156, 2011. PMID:21671354

Hukriede NA and Dawid IB. Making a Tubule the Non-Canonical Way. J Am Soc Nephrol. 22:1575-1577, 2011. PMID:21836144

Seguin SP, Evans CW, Nebane-Akah M, McKellip S, Ananthan S, Tower NA, Sosa M, Rasmussen L, White EL, Maki B, Matharu DS, Golden JE, Aubé J, Brodsky JL, Noah JW. High-Throughput Screening Identifies a Bisphenol Inhibitor of SV40 Large T Antigen ATPase Activity. J Biomol Screen. 17:194-203, 2012. PMID:21948801

Tran JR and Brodsky, JL. Assays to measure ER-associated degradation in yeast. Methods Mol Biol. 832:505-18, 2012. PMC3334846

Grubb S, Guo L, Fisher EA, Brodsky JL. Protein disulfide isomerases contribute differentially to the endoplasmic reticulum-associated degradation of apolipoprotein B and other substrates. Mol Biol Cell. 23(4):520-32, 2012. PMC3279382

Daghestani HN, Zhu G, Johnston PA, Shinde SN, Brodsky JL, Day BW. Characterization of inhibitors of glucocorticoid receptor nuclear translocation: a model of cytoplasmic dynein-mediated cargo transport. Assay Drug Dev Technol. 10:46-60, 2012. PMC3277738

Guerriero CJ and Brodsky JL. On the precipice: the delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation (ERAD) in human physiology. Physiol Rev. 92:537-576, 2012. PMID:22535891 PMC Journal - In Process

Rbaibi Y, Cui S, Mo D, Carattino M., Rohatji R., Satlin LM, Szalinski CM, Antoszewski LM, Fölsch H, Hukriede, NA, and Weisz OA OCRL1 modulates cilia length in renal epithelial cells. Traffic, 13:1295-1301, 2012. PMID: 22680056 PMC Journal - In Process

Mo D, Ihrke G, Costa SA, Brilli L, Labilloy A, Halfter W, Cosentino CC, Hukriede NA, Weisz OA. Apical targeting and endocytosis of the sialomucin endolyn are essential for establishment of zebrafish pronephric kidney function. J Cell Sci. 2012 - in press. PMID:22976307 PMC Journal - In Process

Seguin SP, Ireland AW, Gupta T, Wright CM, Miyata Y, Wipf P, Pipas JM, Gestwicki JE, Brodsky JL. A screen for modulators of large T antigen's ATPase activity uncovers novel inhibitors of Simian Virus 40 and BK virus replication. Antiviral Res. 96(1):70-81, 2012 PMC3465505

Gelling CL, Dawes IW, Perlmutter DH, Fisher EA, Brodsky JL. The Endosomal Protein Sorting Receptor Sortilin Has a Role in Trafficking alpha-1 Antitrypsin. Genetics. 2012 - in press. PMID: 22923381 PMC Journal - In Process

Brilli, L., Swanhart, L.M., de Caestecker, M., and N.A. Hukriede. Histone deacetylase inhibitors in renal development and disease. Pediatric Nephrology. 2012 - in press. PMC Journal - In Process

Buck TM, Brodsky JL. Escaping the endoplasmic reticulum: why does a molecular chaperone leave home for greener pastures? EMBO J. 2015 Jan 2;34(1):1-3. Epub 2014 Nov 25. PMID: 25425576 PMCID: PMC4291476

Buck TM, R Jordan, J Lyons-Weiler, J Adelman, P Needham, TR Kleyman, JL Brodsky. The expression of three topologically distinct membrane proteins elicits unique stress response pathways in the yeast Saccharomyces cerevisiae. Physiological Genomics. In press. PMID:25759377, PMCID: In process

Chiba, T, Skrypnyk, N., Brilli, L, Penchey, R., Zhang, K.X., Rochon, E.R., Fall, J.L., Paueksakon, P., Yang, H., Roman, B.L., Zhang, M-Z., Harris, R., Hukriede, N.A., and M.P. de Caestecker (2015) Retinoic Acid Signaling Coordinates Macrophage-Dependent Injury and Repair after Acute Kidney Injury. JASN In press.

Crum TS, Gleixner AM, Posimo JM, Mason DM, Broeren MT, Heinemann SD, Wipf P, Brodsky JL, Leak RK. Heat shock protein responses to aging and proteotoxicity in the olfactory bulb. J Neurochem. 2015 Jan 29. [Epub ahead of print] PMID: 25640060 PMC Journal – In Process

Brodsky JL, Clark PL. Protein folding in the cell, from atom to organism. FASEB J. 2014 Dec;28(12):5034-8. PMID: 25451678 PMCID: Exempt

Ireland AW, Gobillot TA, Gupta T, Seguin SP, Liang M, Resnick L, Goldberg MT, Manos-Turvey A, Pipas JM, Wipf P, Brodsky JL. Synthesis and structure–activity relationships of small molecule inhibitors of the simian virus 40 T antigen oncoprotein, an anti-polyomaviral target. Bioorg Med Chem. 2014 Nov 15;22(22):6490-502. PMID: 25440730 PMCID: PMC4293281

Needham PG, Patel HJ, Chiosis G, Thibodeau PH, Brodsky JL. Mutations in the Yeast Hsp70, Ssa1, at P417 Alter ATP Cycling, Interdomain Coupling, and Specific Chaperone Functions. J Mol Biol. 2015 Apr 23. [Epub ahead of print] PMID: 25913688 PMC Journal – In Process

Posimo JM, Weilnau JN, Gleixner AM, Broeren MT, Weiland NL, Brodsky JL, Wipf P, Leak RK. Heat shock protein defenses in the neocortex and allocortex of the telencephalon. Neurobiol Aging. 2015 May;36(5):1924-37. Epub 2015 Feb 18. PMID: 25771395 PMCID: PMC4417007

Surlow BA, Cooley BM, Needham PG, Brodsky JL, Patton-Vogt J. Loss of Ypk1, the yeast homolog to the human serum- and glucocorticoid-induced protein kinase, accelerates phospholipase B1-mediated phosphatidylcholine deacylation. J Biol Chem. 2014 Nov 7;289(45):31591-604. Epub 2014 Sep 25. PMID: 25258318 PMCID: PMC4223355